Introduction
Introduction
The U-PGx Personalized Medicine Symposium will be organized, as a HYBRID meeting, in Leiden, the Netherlands on March 30-31st, 2022.
The meeting will be co-organized by the Golden Helix Foundation and the Leiden University Medical Center, both partners of the Ubiquitous Pharmacogenomics (U-PGx) project, funded by the European Commission (H2020-668353). This international event is open for clinical pharmacologists, hospital pharmacists, general pharmacists, specialists, general practitioners, medical students, laboratory technicians, regulators, healthcare insurers and others interested in pharmacogenomics.
IMPORTANT NOTICE: Please note that registered participants will attend remotely, while Consortium members and speakers will participate with physical presence
We look forward to a successful meeting.
On behalf of the Organizing Committee
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Co-organized by:
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Funded by:
This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 668353.
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Scientific Program
Draft Scientific Program
Day 1 - 30 March 2022
08.45 – 09.15: Welcome / coffee
09.15 - 09.30: Opening address by Prof Henk-Jan Guchelaar
09.30 - 11.00: Session UK Pharmacogenetics and Stratified Medicine Network
(Chair: Prof. Sir Munir Pirmohamed)
09.30 – 10.00: Prof Sir Mark Caulfield
Pharmacogenomics and the 100,000 genomes project
10.00 – 10.30: Prof Dame Sue Hill
Implementing pharmacogenomics into the NHS
10.30 – 11.00: Prof Sir Munir Pirmohamed
Deep phenotype vs large datasets: moving pharmacogenomics forward
11.00 – 11.30: Coffee break
11.30 – 13.00: Session Spanish Infrastructure of Precision Medicine associated with Science and Technology (IMPaCT)
(Chair: Prof. Adrian Llerena)
11.30 – 12.00: Prof. Angel Carracedo
IMPaCT: The national strategy of Personalised Medicine Genomic phrame
12.00 – 12.30: Prof. Adrian Llerena
Case example implementation: MedeA
12.30 – 13.00: Prof. Fernando Martin-Sanchez
The role of Digital Health in Personalised Medicine
13.00 - 14.00: Lunch break
14.00 – 16.00: Session Regulation & Society
(Chair: Prof. Magnus Ingelman-Sundberg-Sundberg)
14.00 – 14.30: Christopher Stevens aka Lord Elpus
DPD, A Testing Time
14.30 – 15.00: Jan Berkelmans
The value of Personalized Medicine and Pharmacogenetics testing
15.00 – 15.30: George P. Patrinos
Harmonization of pharmacogenomics guidance: The European Medicines Agency and other international approaches
15.30 – 16.00: Michael Pacanowski
Regulatory considerations for genotype-guided therapy in the U.S.
16.00 – 16.30: Coffee break
16.30 – 18.00: Session U-PGx consortium
(Chair: Prof. Henk-Jan Guchelaar)
16.30 – 17.00: Matthias Samwald
Overcoming borders and barriers: Enabling PGx across Europe in the U-PGx project
17.00 – 17.30: Jesse Swen
Results of the PREPARE trial
17.30 – 18.00: Matthias Schwab
Future direction of systems pharmacology and personalized medicine
18.00 – 19.30: Dinner buffet
19.30 – 21.00: Session PGRN
(Chair: Dr. Andrew Monte)
19.30 – 20.00: Kelly Caudle
Resources for implementing pharmacogenetics into routine clinical practice
20.00 – 20.30: Todd Skaar
Lessons learned from the pragmatic Pharmacogenetics-guided INGENIOUS trial
20.30 – 21.00: Andrew Monte
The PGRN: Globalizing PGx Research Collaboration
Day 2 - 31 March, 2022
08.45 – 09.00: Welcome / coffee
09.00 – 10.30: Session FUSAFE network
(Chair Marie Christine Etienne-Grimaldi)
09.00 – 09.30: Marie Christine Etienne-Grimaldi
Dihydropyrimidine deshydrogenase gene variants for predicting grade 4-5 fluoropyrimidine-induced toxicity: Results of FUSAFE individual patient data meta-analysis
09.30 – 10.00: Marie-Anne Loriot
French experience of nationwide implementation of uracilemia testing, and its impact on fluoropyrimidine-related toxicities based on pharmacovigilance data collection
10.00 – 10.30: Marie Christine Etienne-Grimaldi
Current perspectives of FUSAFE and other fluoropyrimidine pharmacogenetic projects
10.30 - 11.00: Coffee break
11:00 - 12:30 Session European Society of Pharmacogenomics and Personalised Therapy
(Chairs: Prof. Vangelis Manolopoulos and Prof. Adrian Llerena)
11.00 – 11.30 Vangelis Manolopoulos
European Society of Pharmacogenomics and Personalised Therapy: The first 10 years
Direct oral anticoagulants: OMICS approaches for biomarker generation and personalised clinical implementation
11.30 – 12.00 Ann Daly
Hepatic adverse drug reactions to antimicrobials: Predictable?
12.00 – 12.30 Ron H. van Schaik
Pharmacogenomics in clinical care: Harmonization of CYP2D6 testing and status of CYP3A4 genotyping
12.30 - 13.30: Lunch break
13.30 - 15.00: Session Socioeconomic aspects
(Chair: Prof. Henk-Jan Guchelaar)
13.30 – 14.00 Μatthijs Versteegh
The net and societal benefit of personalised medicine: Review and case study
14.00 – 14.30 David Haerry
Personalized medicine, an opportunity to redefine value in healthcare by incorporating patient preference and socio-economic aspects
14.30 – 15.00 Arie Dijkstra
Social psychology: What is the impact of the CoViD-19 pandemic on pre-emptive oharmacogenetic testing?
15.00: Closing remarks - Prof. Henk-Jan Guchelaar
