Introduction

17th Golden Helix Pharmacogenomics Day

Erasmus University Medical Center

Queridozaal Lecture Hall

27 May 2016, Rotterdam, the Netherlands

The 17th Golden Helix Pharmacogenomics day will be organized in the Queridozaal of the Erasmus University Medical Center in Rotterdam, the Netherlands. The meeting will be co-organized from the Erasmus MC, Department of Clinical Chemistry, the European Pharmacogenomics Implementation Consortium (Eu-PIC), the Dutch Clinical Chemistry Society and the Golden Helix Foundation.

This international event is open for clinical chemists, hospital pharmacists, general pharmacists, specialists, general practitioners, medical students, laboratory technicians, regulators, healthcare insurers and others interested in pharmacogenomics.

The symposium will take place at Erasmus MC, Wytemanweg 80, Rotterdam in the Querido room of the Educational Center. Rotterdam can be reached from Schiphol airport by high speed train (25 min). From Rotterdam Central station, a taxi can bring you to Erasmus MC, entrance Wytemaweg. For metro, use exit Dijkzigt,which is closest to entrance Wytemaweg. For car, you can use parking Westzeedijk or Museumpark

On behalf of the Organizing Committee

Co-organized by:

Under the auspices of:

Speakers

Organizing Committee

Ron H. van Schaik, Professor; Erasmus MC, Department of Clinical Chemistry; Coordinator; European Pharmacogenomics Implementation Consortium

George P. Patrinos, Associate Professor; University of Patras School of Health Sciences, Department of Pharmacy, Patras, Greece

Committee Molecular Biology Diagnostics (CMBD) NVKC

Invited speakers and moderators

Joachim Aerts, Rotterdam, NL

Maarten Akkerman, Leusden, NL

Norma Anwar, London, UK

Marieke Coenen, Nijmegen, NL

Vera Deneer, The Hague, NL

Maurizio Ferrari, Milan, IT

Henk-Jan Guchelaar, Leiden, NL,

Linda Henricks, Amsterdam, NL

Tim Hubbard, London, UK

Magnus Ingelman-Sundberg, Stockholm, SE

Julie Johnson, Tampa, FL, USA

Vangelis G. Manolopoulos, Alexandroupolis, GR

Mikko Niemi, Helsinki, FI

George P. Patrinos, Patras, GR

Markus Paulmichl, Salzburg, AT

Marzia del Re, Pisa, IT

Ron van Schaik, Rotterdam, NL

Matthias Schwabb, Stuttgart, DE

Jesse Swen, Leiden, NL

Andre Uitterlinden, Rotterdam, NL

Teun van Gelder, Rotterdam, NL

Emile Voest, Amsterdam, NL

Scientific Program

8:00 Registration

Welcome Addresses

08:45 Ron van Schaik, Professor; Erasmus MC, Department of Clinical Chemistry, Rotterdam, the Netherlands; Coordinator; European Pharmacogenomics Implementation Consortium (Eu-PIC)

08:50 George P. Patrinos, Associate Professor; University of Patras School of Health Sciences, Department of Pharmacy, Patras, Greece

08:55 Maurizio Ferrari, President, International Federation of Clinical Chemistry (IFCC) representative

Session I: Clinical Implementation - Chairs: M. Ferrari, R.H. van Schaik

09:00 - 09:15 Drs Edith Schippers (tbc), Minister of Health

09:15 - 09:40 KEYNOTE LECTURE - Improving clinical outcomes with Pharmacogenomics

Prof. Julie Johnson, University of Florida, Tampa, FL, USA

09:40 - 10:00Implementation of Pharmacogenomics in Austria

Prof. Markus Paulmichl, Paracelsus University, Salzburg, AT

10:00 - 10:20 Sequencing rare variants: the next step in Pharmacogenomics

Prof. Magnus Ingelman-Sundberg, Karolinska Institutet, Stockholm, SE

10:20 - 10:45 COFFEE BREAK

Session II: Evidence for Clinical Use - Chairs: G. P. Patrinos, T. van Gelder

10:45 - 11:05TPMT genotyping for thiopurine treatment

Dr. Marieke Coenen,Radboud University, Nijmegen, NL

11:05 - 11:25 Clinical value of DPYD genotyping

Dr. Linda Henricks, Netherlands Cancer Institute (NKI), Amsterdam, NL

11:25 - 11:45 Tamoxifen and CYP2D6 : where do we stand today?

Prof. Matthias Schwabb, Margarete Fisher Bosch Institute, Stuttgart, DE

11:45 - 12:05 Pharmacogenomics for improving statin treatment

Prof. Mikko Niemi, University of Helsinki, Helsinki, FI

12:05 - 13:00 LUNCH BREAK - Foyer 3rd floor outside Querido room

Session III: Using Pharmacogenomics for Diagnostics - Chairs: J. Swen, M. Paulmichl

13:00 - 13:15 Evidence-based dosing based on genotype

Dr. Vera Deneer, KNMP Pharmacogenomics Working Group, den Haag, NL

13:15 - 13:30 Pharmacogenomics information in drug labels

Dr. Norma Anwar, European Medicine Agency, London, UK

13:30 - 13:45The position of the Health Care Insurer

Dr. Maarten Akkerman, Hospital Care ACHMEA, Leusden, NL

Session IV: Genotyping and Translation - Chairs: Y. B. de Rijke, D. A. v/d Broek

13:45 - 14:00 Using Next Generation Sequencing for Pharmacogenomics

Prof. George P. Patrinos, University of Patras, Department of Pharmacy, Patras. GR

COMPANY LECTURES

14:00 - 14:15 A new tool for pre-emptive pharmacogenetic testing

Dr. Dominique de Wolf, ThermoFisher, BE

14:15 - 14:30Actionable Pharmacogenomics reporting software

Dr. Fareed Kureshy, AUTOGENOMICS, USA

14:30 - 14:45 A portal for reporting Pharmacogenomics results

Prof. Daniela Steinberger, Bio.Logis, DE

14:45 - 15:00Translational tools for Pharmacogenomics results

Dr. Jari Forsstm, Abomics

15:00 - 15:25 TEA BREAK

Session V: Personalized Drug Therapy - Chairs: J. Aerts, A. Uitterlinden

15:25 - 15:50The Genomics England initiative: 100,000 genomes

Prof. Tim Hubbard, Genomics England, London, UK

15:50 - 16:15 Sequencing the tumor genome: the CPCT approach

Dr. Emile Voest, Netherlands Cancer Institute (NKI), Amsterdam, NL

16:15 - 16:40Cell-free DNA analysis for lung and prostate cancer

Dr. Marzia del Re, University of Pisa, Pisa, IT

Session VI: European Initiatives - Chairs: M. Ferrari, V. Deneer

16:40 - 16:55European Society of Pharmacogenomics & Personalized Therapy

Prof. Vangelis G. Manolopoulos, Democritus University of Thrace, Alexandroupolis, GR; Vice-President;European Society of Pharmacogenomics & Personalized Therapy (ESPT)

16:55 - 17:10 European Pharmacogenomics Implementation Consortium

Prof. Ron H. van Schaik, Erasmus MC, Department of Clinical Chemistry, Rotterdam, NL; Coordinator; European Pharmacogenomics Implementation Consortium (Eu-PIC)

17:10 - 17:25 The HORIZON2020 U-PGx project

Prof. Henk-Jan Guchelaar, Leiden University Medical Center, Leiden, NL, Coordinator; UPGx Consortium

17:25 - 17:30 Conclusions and wrap up

Prof. Ron H. van Schaik, Erasmus MC, Department of Clinical Chemistry, Rotterdam, NL; Coordinator; European Pharmacogenomics Implementation Consortium (Eu-PIC)

17:30 Drinks and Networking Opportunity