Welcome page

Welcome to the HbVar-XPRbase. This is an online repository of information about the different experimental protocols available to screen for sequence variations inside the human globin genes, leading to thalassemia and/or hemoglobin variants. This database, a useful supplementary tool to the main HbVar database for hemoglobin variants and thalassemia mutations, resulted from the fruitful collaboration between several investigators from Erasmus University Medical Center (The Netherlands) and the University of Thessaly, Greece. The project has initiated and financially supported by Asclepion Genetics (Switzerland) and by the European Commission collaboration action ITHANET (RI 026539).

The initial data came from previously published reports as well as from unpublished information contributed from individual researchers prior of publication. This information was converted to a database, and now new entries are added and old entries are corrected by our expert advisors and collaborators.

Visit the Protocols page to query the available information for every experimental protocol related to human globin gene mutation screening. Please note however, that HbVar-XPRbase is currently being updated with new protocols on a regular basis. The first version of the database has been launched in March 2005 and in its current second version, the database includes 51 protocols related to human globin gene mutation screening.

Citing this resource:

HbVar Database of Human Hemoglobin Variants and Thalassemias: 2007 Update. In preparation.

Publications:

1. DNA, diseases and databases: Disastrously deficient. (2005). Trends Genet. 21:333-338.
2. Molecular diagnosis of inherited disorders: Lessons from hemoglobinopathies. (2005). Hum. Mutat. 25:399-412.

Database design by George P. Patrinos and Sjozef van Baal

© Copyright 2004-2006 by Asclepion Genetics and Golden Helix